Genetic screening for medicine and dosage combinations | Kailos
 
 

Wouldn’t you like to know how medicine will work for you BEFORE it’s prescribed?

Whether you find yourself in the ER, preparing for a root canal, recovering from a heart attack or dealing with a cancer diagnosis, you want to know that the treatments you are receiving are working properly. Due to changes in DNA, many people will have a slower response or no response to specific medications, while others may experience increased side effects.

How Kailos can help you

Finding out during treatment or after the fact, that a certain medicine was not the right one can be avoided. Since everyone’s genes are different, knowing how you will respond to medicines in advance of treatment gives you and your physician the knowledge to prescribe treatment confidently. With Kailos’ PGxComplete report, you can work with your physician to select the right medicine and dosage combination for you based on your DNA, so that you get the desired effects of treatment ranging from pain relief, to cancer therapy. The Kailos test lets you know how you will respond to medication before you need it so you are informed and prepared.

PGxComplete, $299

Why would I respond differently?

There are many different types of genes in your DNA that control how your body uses medications. Kailos looks carefully at these genes to see how they can affect your treatment.

While some genes may affect a specific part of treatment, others may have broader impacts. For instance, the ‘CYP’ genes (i.e. CYP2D6, CYP2C19, CYP2C9, CYP3A4) are involved in how your body uses a majority of medications. However, CYP2D6 is involved in 25% of all medications. Additionally, a combination of these genes may cause different responses. This is the case with the cholesterol lowering medications (statins), where three genes (ABCB1, CYP3A5 & SLCO1B1) need to be combined to understand your response.

Some genes can impact how your body uses medicines in a good way by leading to better treatment response, a smaller required dosage and less cost for medication. However, some genes can cause negative reactions including harmful side effects or no effect at all. The good news is that alternate treatments are usually available. By understanding how your body uses medicines, you and your physician are able to immediately select the best treatment for your DNA.

Order the Kailos test today and get the most out of your treatment!

PGxComplete, $299

What genes are tested to make my PGxComplete report?

Gene Gene Gene Gene
ABCB1 CYP2C19 F2 MTHFR
ABCG2 CYP2C9 F5 NR1H3
ADRA2A CYP2D6 GNB3 OPRM1
ADRB1 CYP3A4 GRIK4 RYR1
AGT CYP3A5 HTR1A SLC6A2
CACNA1C DPYD HTR2A SLCO1B1
CES1 DRD1 HTR2C TPMT
CFTR DRD2 IFNL3 VKORC1
COMT DRD3 KCNIP1  
CYP1A2 EDN1 LDLR  

What is covered?

Medicine classes Generic medicine name
ADHD Medications Amphetamine, Atomoxetine, Clonidine, Dexmethylphenidate, Dextroamphetamine, Lisdexamfetamine, Methylphenidate
Antiarrhythmics Digoxin, Flecainide, Propafenone
Anticoagulants Warfarin
Antidepressants Amitriptyline, Citalopram, Clomipramine, Desipramine, Doxepin, Duloxetine, Escitalopram, Imipramine, Nortriptyline, Paroxetine, Sertraline, Trimipramine, Venlafaxine
Antidiabetics Repaglinide, Tolbutamide
Antiepileptics Mephenytoin, Phenytoin, Valproic Acid
Antihypertensives Atenolol, Benazepril, Enalapril, Imidapril, Irbesartan, Losartan, Metoprolol, Timolol, Verapamil
Antipsychotics Aripiprazole, Clozapine, Haloperidol, Olanzapine, Risperidone
Benzodiazepines Diazepam
Chemotherapeutics Capecitabine, Cisplatin, Cyclophosphamide, Fluorouracil, Leucovorin, Mercaptopurine, Methotrexate, Oxaliplatin, Paclitaxel, Tamoxifen, Tegafur, Thioguanine
Corticosteroids Prednisone
General Anesthetics Desflurane, Isoflurane, Nitrous Oxide, Sevoflurane, Succinylcholine
Hepatitis Antivirals Peginterferon-alfa, Ribavirin
HIV/AIDS Antivirals Efavirenz, Nelfinavir, Nevirapine
Immunosuppressants Azathioprine, Cyclosporine, Sirolimus, Tacrolimus
Muscle Relaxants Carisoprodol
NSAIDs Celecoxib, Diclofenac
Opioids Codeine, Hydrocodone, Oxycodone, Tramadol
Platelet Aggregation Inhibitors Clopidogrel
Proton Pump Inhibitors Lansoprazole, Omeprazole, Pantoprazole
Statins Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin
Thrombophilia Risk factor for blood clot development