Prevent-2.1.5.1

Prevent-2.1.5.1 Genes Targeted

The Kailos Genetics Prevent (v2.1.5.1) panel targets the coding regions and splice junctions for the following genes as defined by the union of RefSeq transcripts below.

.gene td { padding-left: 10px; padding-right: 10px; vertical-align: top; } .gene th { padding-left: 10px; padding-right: 10px; } Gene Symbol Transcripts APOB NM_000384 ATM NM_000051 BRCA1 NM_007294, NM_007297, NM_007298, NM_007299, NM_007300, NR_027676 BRCA2 NM_000059 CHEK2 NM_001005735, NM_001257387, NM_007194, NM_145862 EPCAM NM_002354 LDLR NM_000527, NM_001195798, NM_001195799, NM_001195800, NM_001195803 MLH1 NM_000249, NM_001167617, NM_001167618, NM_001167619, NM_001258271, NM_001258273, NM_001258274 MSH2 NM_000251, NM_001258281 MSH6 NM_000179, NM_001281492, NM_001281493, NM_001281494 NBN NM_001024688, NM_002485 PALB2 NM_024675 PCSK9 NM_174936, NR_110451 PMS2 NM_000535, NM_001322003, NM_001322004, NM_001322005, NM_001322006, NM_001322007, NM_001322008, NM_001322009, NM_001322010, NM_001322011, NM_001322012, NM_001322013, NM_001322014, NM_001322015, NR_136154 Prevent-2.1.5.1 Reportable Range

The Kailos Genetics Prevent (v2.1.5.1) Panel will report any CLINVAR pathogenic or likely pathogenic variant found in the following regions.

Gene Symbol Range* APOBchr2:21224478-21226326 APOBchr2:21227099-21227629 APOBchr2:21227901-21228703 APOBchr2:21228708-21229126 APOBchr2:21229139-21232495 APOBchr2:21232499-21235549 APOBchr2:21235967-21236469 APOBchr2:21237254-21237529 APOBchr2:21237901-21238178 APOBchr2:21238191-21238469 APOBchr2:21239277-21239555 APOBchr2:21241786-21242064 APOBchr2:21242547-21242825 APOBchr2:21245670-21245944 APOBchr2:21246342-21246618 APOBchr2:21247762-21248040 APOBchr2:21249609-21249887 APOBchr2:21250680-21250964 APOBchr2:21251166-21251444 APOBchr2:21252456-21252967 APOBchr2:21255201-21255479 APOBchr2:21256142-21256420 APOBchr2:21257592-21257870 APOBchr2:21258379-21258657 APOBchr2:21259911-21260181 APOBchr2:21260768-21261046 APOBchr2:21263744-21264024 APOBchr2:21265152-21265430 APOBchr2:21266265-21266530 APOBchr2:21266638-21266911 ATMchr11:108098321-108098698 ATMchr11:108099826-108100066 ATMchr11:108106336-108106618 ATMchr11:108114564-108114655 ATMchr11:108114679-108114922 ATMchr11:108115495-108115773 ATMchr11:108117634-108117913 ATMchr11:108119558-108119606 ATMchr11:108119736-108119878 ATMchr11:108121378-108121409 ATMchr11:108121426-108121804 ATMchr11:108122528-108122800 ATMchr11:108123451-108123731 ATMchr11:108124518-108124793 ATMchr11:108126820-108126893 ATMchr11:108126927-108127097 ATMchr11:108128132-108128410 ATMchr11:108129619-108129897 ATMchr11:108137845-108138123 ATMchr11:108139073-108139380 ATMchr11:108141713-108141897 ATMchr11:108142034-108142195 ATMchr11:108143193-108143641 ATMchr11:108150138-108150186 ATMchr11:108150214-108150397 ATMchr11:108151647-108151928 ATMchr11:108153398-108153678 ATMchr11:108154951-108155217 ATMchr11:108158246-108158285 ATMchr11:108158315-108158524 ATMchr11:108159628-108159890 ATMchr11:108160288-108160572 ATMchr11:108163248-108163293 ATMchr11:108163552-108163597 ATMchr11:108163973-108164008 ATMchr11:108164039-108164239 ATMchr11:108165590-108165859 ATMchr11:108167947-108168206 ATMchr11:108170388-108170668 ATMchr11:108172307-108172585 ATMchr11:108173529-108173805 ATMchr11:108175352-108175632 ATMchr11:108178529-108178807 ATMchr11:108180801-108181082 ATMchr11:108183042-108183321 ATMchr11:108186452-108186928 ATMchr11:108188028-108188206 ATMchr11:108188280-108188307 ATMchr11:108190614-108190866 ATMchr11:108191955-108192197 ATMchr11:108196015-108196293 ATMchr11:108196753-108197001 ATMchr11:108198309-108198568 ATMchr11:108199718-108199996 ATMchr11:108200906-108201184 ATMchr11:108202114-108202297 ATMchr11:108202543-108202825 ATMchr11:108203419-108203692 ATMchr11:108204533-108204799 ATMchr11:108205633-108205893 ATMchr11:108206491-108206716 ATMchr11:108213885-108214163 ATMchr11:108216455-108216692 ATMchr11:108217910-108218188 ATMchr11:108224411-108224639 ATMchr11:108225431-108225714 ATMchr11:108235738-108236016 ATMchr11:108236023-108236278 BRCA1chr17:41197596-41197874 BRCA1chr17:41199551-41199754 BRCA1chr17:41201076-41201269 BRCA1chr17:41202968-41203246 BRCA1chr17:41209002-41209220 BRCA1chr17:41215271-41215509 BRCA1chr17:41215789-41216069 BRCA1chr17:41219530-41219768 BRCA1chr17:41222919-41223286 BRCA1chr17:41226304-41226582 BRCA1chr17:41228421-41228703 BRCA1chr17:41231245-41231497 BRCA1chr17:41234368-41234646 BRCA1chr17:41242866-41243144 BRCA1chr17:41243338-41246976 BRCA1chr17:41247762-41248079 BRCA1chr17:41249189-41249483 BRCA1chr17:41251706-41251984 BRCA1chr17:41256124-41256356 BRCA1chr17:41256790-41257074 BRCA1chr17:41258373-41258651 BRCA1chr17:41267661-41267838 BRCA1chr17:41267860-41267909 BRCA1chr17:41275974-41276227 BRCA2chr13:32890473-32890751 BRCA2chr13:32893194-32893478 BRCA2chr13:32899143-32899333 BRCA2chr13:32899356-32899424 BRCA2chr13:32900164-32900468 BRCA2chr13:32900542-32900821 BRCA2chr13:32903463-32903748 BRCA2chr13:32904973-32905211 BRCA2chr13:32906382-32907552 BRCA2chr13:32910366-32915348 BRCA2chr13:32918604-32918832 BRCA2chr13:32920856-32921142 BRCA2chr13:32928953-32929462 BRCA2chr13:32930512-32930795 BRCA2chr13:32931844-32932117 BRCA2chr13:32936604-32936884 BRCA2chr13:32937242-32937720 BRCA2chr13:32944449-32944727 BRCA2chr13:32945026-32945307 BRCA2chr13:32950729-32951007 BRCA2chr13:32953415-32953682 BRCA2chr13:32953830-32954108 BRCA2chr13:32954115-32954361 BRCA2chr13:32968817-32969087 BRCA2chr13:32970969-32971247 BRCA2chr13:32972270-32972966 CHEK2chr22:29083714-29083992 CHEK2chr22:29085024-29085302 CHEK2chr22:29089924-29090202 CHEK2chr22:29091016-29091365 CHEK2chr22:29091641-29091925 CHEK2chr22:29092789-29093071 CHEK2chr22:29095757-29096018 CHEK2chr22:29099413-29099654 CHEK2chr22:29105924-29106154 CHEK2chr22:29107802-29108065 CHEK2chr22:29115295-29115560 CHEK2chr22:29120900-29121155 CHEK2chr22:29121176-29121432 CHEK2chr22:29126393-29126561 CHEK2chr22:29130302-29130724 EPCAMchr2:47596553-47596624 EPCAMchr2:47600517-47600795 EPCAMchr2:47600928-47601206 EPCAMchr2:47602253-47602531 EPCAMchr2:47604046-47604324 EPCAMchr2:47605977-47606265 EPCAMchr2:47606858-47607045 EPCAMchr2:47607105-47607142 EPCAMchr2:47612169-47612436 EPCAMchr2:47613688-47613966 LDLRchr19:11200119-11200371 LDLRchr19:11210853-11211034 LDLRchr19:11213301-11213497 LDLRchr19:11215803-11216322 LDLRchr19:11217203-11217409 LDLRchr19:11218033-11218243 LDLRchr19:11221296-11221494 LDLRchr19:11222135-11222371 LDLRchr19:11223901-11224142 LDLRchr19:11224192-11224464 LDLRchr19:11226712-11226929 LDLRchr19:11227491-11227701 LDLRchr19:11230739-11230956 LDLRchr19:11231013-11231229 LDLRchr19:11233793-11234086 LDLRchr19:11238624-11238826 LDLRchr19:11240146-11240400 LDLRchr19:11241853-11242091 MLH1chr3:37034967-37035179 MLH1chr3:37035186-37035464 MLH1chr3:37038016-37038294 MLH1chr3:37042354-37042627 MLH1chr3:37045790-37046068 MLH1chr3:37048379-37048667 MLH1chr3:37050212-37050490 MLH1chr3:37053193-37053685 MLH1chr3:37055840-37056118 MLH1chr3:37058905-37059183 MLH1chr3:37061734-37062017 MLH1chr3:37067226-37067508 MLH1chr3:37070230-37070488 MLH1chr3:37081592-37081870 MLH1chr3:37083652-37083917 MLH1chr3:37088953-37089201 MLH1chr3:37089915-37090193 MLH1chr3:37090313-37090591 MLH1chr3:37091913-37092191 MSH2chr2:47630340-47630525 MSH2chr2:47635478-47635522 MSH2chr2:47635562-47635815 MSH2chr2:47637158-47637202 MSH2chr2:47637228-47637592 MSH2chr2:47639452-47639724 MSH2chr2:47641447-47641558 MSH2chr2:47641606-47641657 MSH2chr2:47643363-47643641 MSH2chr2:47656878-47657120 MSH2chr2:47672603-47672879 MSH2chr2:47690093-47690369 MSH2chr2:47693751-47694011 MSH2chr2:47698016-47698063 MSH2chr2:47698085-47698284 MSH2chr2:47702146-47702426 MSH2chr2:47703463-47703747 MSH2chr2:47705394-47705675 MSH2chr2:47707784-47708068 MSH2chr2:47709888-47710175 MSH6chr2:48010366-48010579 MSH6chr2:48017989-48018235 MSH6chr2:48018316-48018344 MSH6chr2:48022994-48023257 MSH6chr2:48025646-48028374 MSH6chr2:48030467-48030867 MSH6chr2:48031969-48032246 MSH6chr2:48032713-48032739 MSH6chr2:48032754-48032974 MSH6chr2:48033287-48033534 MSH6chr2:48033562-48033831 MSH6chr2:48033856-48033882 MSH6chr2:48033917-48034047 NBNchr8:90947587-90947907 NBNchr8:90949140-90949472 NBNchr8:90955399-90955737 NBNchr8:90958307-90958632 NBNchr8:90959918-90960225 NBNchr8:90965461-90965944 NBNchr8:90967396-90967871 NBNchr8:90970872-90971197 NBNchr8:90976528-90976816 NBNchr8:90982525-90982860 NBNchr8:90983303-90983632 NBNchr8:90990367-90990697 NBNchr8:90992897-90993247 NBNchr8:90993538-90993847 NBNchr8:90994878-90995088 NBNchr8:90995110-90995224 NBNchr8:90996783-90996933 PALB2chr16:23614600-23615018 PALB2chr16:23619120-23619398 PALB2chr16:23625230-23625508 PALB2chr16:23632602-23632880 PALB2chr16:23634229-23634510 PALB2chr16:23635234-23635511 PALB2chr16:23637499-23637777 PALB2chr16:23640434-23640698 PALB2chr16:23640899-23641849 PALB2chr16:23646105-23646141 PALB2chr16:23646166-23647664 PALB2chr16:23647715-23647727 PALB2chr16:23649090-23649560 PCSK9chr1:55505475-55505781 PCSK9chr1:55509473-55509727 PCSK9chr1:55512153-55512350 PCSK9chr1:55517906-55518110 PCSK9chr1:55518265-55518497 PCSK9chr1:55521620-55521869 PCSK9chr1:55522966-55523223 PCSK9chr1:55523678-55523917 PCSK9chr1:55524167-55524325 PCSK9chr1:55525109-55525384 PCSK9chr1:55527000-55527278 PCSK9chr1:55529011-55529289 PMS2chr7:6012800-6013272 PMS2chr7:6017165-6017443 PMS2chr7:6018213-6018416 PMS2chr7:6022400-6022656 PMS2chr7:6026568-6027294 PMS2chr7:6029368-6029616 PMS2chr7:6031507-6031785 PMS2chr7:6035076-6035354 PMS2chr7:6036924-6037056 PMS2chr7:6037075-6037145 PMS2chr7:6038684-6038829 PMS2chr7:6038839-6038984 PMS2chr7:6042037-6042315 PMS2chr7:6043217-6043473 PMS2chr7:6043507-6043697 PMS2chr7:6043726-6043759 PMS2chr7:6045454-6045732 PMS2chr7:6048604-6048752

* Ranges shown in hg19 / GRCh37 coordinates

 

Prevent-2.1.5.1 Regions Excluded

The Kailos Genetics Prevent (v2.1.5.1) Panel will not report on the following coding regions.

Gene Symbol Regions Excluded* Exclusion Length (bp) APOB chr2:21228704-21228707 4 APOB chr2:21229127-21229138 12 APOB chr2:21232496-21232498 3 ATM chr11:108119660-108119735 76 ATM chr11:108141978-108142033 56 ATM chr11:108163346-108163520 175 ATM chr11:108188207-108188248 42 EPCAM chr2:47596645-47596720 76 EPCAM chr2:47607046-47607104 59 MLH1 chr3:37067128-37067225 98 MSH2 chr2:47630331-47630339 9 MSH2 chr2:47630526-47630541 16 MSH2 chr2:47635540-47635561 22 MSH2 chr2:47641408-47641446 39 MSH6 chr2:48010580-48010632 53 MSH6 chr2:48018236-48018262 27 NBN chr8:90996753-90996782 30 PALB2 chr16:23652431-23652478 48 PMS2 chr7:6026390-6026567 178 PMS2 chr7:6038830-6038838 9