For many medications to work, they need to be metabolized, or changed into a form where they have an effect. Certain variations in DNA limit the effect of some medications. For example, some pain medications have to be activated in order for a patient to feel the relief. Alternatively, different DNA changes can cause pain medications to reach the patients system more rapidly than expected, in rare cases leading to an overdose with the ‘normal’ dosage.
Learn more about what DNA changes impact how medications work.